As India's Covid epidemic worsens, so does prevalence of a "double mutation" variant, which has mutations E484Q (like E484K) and L452R (found in CA variant). Now classified as B.1.617 – it's gone from 24% of sequenced samples in February to 80% on April 1.

 The "double mutation" refers to two specific changes: The E484Q mutation (glutamate is replaced by glutamine at the 484th spot of the spike protein) and the L452R mutation (leucine is replaced by arginine at the 452nd position). (Scott Gottlieb, MD)

 

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